These may include: Blurry vision or double vision. Ovarian enlargement may also occur, which can present with significant abdominal pain or pelvic pain, weight gain, or significant bloating If you experience any of these side effects, check with your doctor as soon as possible. This is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.
You May Also Like. The Types and Uses of Fertility Drugs. Medication for IVF Infographic. We use cookies on this site to enhance your user experience and your privacy is very important to us. Also be sure to get plenty of fluids, since mild dehydration can cause headaches. This is a frustrating potential side effect of clomiphene, as thick or absent cervical fluid can interfere with achieving pregnancy. Cervical mucus is needed to help transport the sperm into the cervix.
If clomiphene causes thick cervical mucus, this can decrease the chances of getting pregnant. Let your doctor know if this happens during treatment. They can consider whether clomiphene is the right drug for you, or find a way to treat or bypass the problem like with IUI treatment.
You may want to try using a sperm-friendly lubricant to make sex more comfortable. A frightening, but usually not dangerous, side effect of clomiphene is blurred vision.
It occurred in 1. This is more likely at higher doses. Vision disturbances may include:. Obviously, you should take care in driving or operating dangerous equipment if you experience visual side effects. If you experience vision changes, be sure to contact your doctor right away.
The symptoms should go away once the medication is stopped. While side effects are usually physical or emotional discomforts experienced while taking a drug, a drug's risks are what may occur beyond what you feel. With that said, here are the possible risks to Clomid:. Twin or multiple pregnancy : The risk of getting pregnant with twins or more may be the most well-known side effect of clomiphene.
To reduce the chances of having twins, your doctor should always start you on the lowest dose first. Additionally, your doctor can do a mid-cycle scan to estimate the number of follicles and determine whether or not there is a high probability of twins or multiples. Together, you can determine at that time if you want to skip that cycle of proceed accordingly.
Ovarian hyperstimulation syndrome OHSS : Usually mild with clomiphene treatment, but in rare cases, the severe form can occur. Without treatment, severe OHSS can be life-threatening. If you experience nausea, severe abdominal or pelvic pain, sudden weight gain, or severe bloating, contact your doctor immediately.
Irreversible vision disturbances : Extremely rare, only in those who continue treatment after vision disturbance began. In those who discontinued treatment, vision disturbance stopped after three days. Ovarian cysts : The cyst is typically benign not cancerous , and it should go away on its own not long after the treatment cycle is over.
If the cyst does not go away, the doctor should follow up and reevaluate. In rare cases, it may require surgical intervention. Ovarian cancer : Some studies have found an increased risk of ovarian cancer if clomiphene is taken for a year or longer. It's unclear if this is caused by clomiphene or infertility itself.
You can't completely avoid potential side effects of Clomid or eliminate all risks, but there are things you or your doctor can do to help possibly reduce them. Get diet and wellness tips to help your kids stay healthy and happy. Rebar RW. Ovulatory Dysfunction. Patients not monitored with an ultrasound might be unaware of this side effect. Therefore, every serious fertility expert will always perform a transvaginal ultrasound in a Clomid cycle. We always want to document how many follicles developed and the endometrial thickness.
Common Clomid side effects include hot flashes, headache, blurry vision, mood swings, and can induce a change in cervical mucus. Clomiphene works directly on the pituitary gland and also affects many tissues with estrogen receptors. This is in contrast to injectable gonadotropins like Gonal-F that targets primarily just the ovary. Therefore many patients will notice changes in their body during the Clomid cycle. Fortunately, none of these is a long-lasting side effect, and there are no long-term effects.
While some concern was raised regarding ovarian cancer, there is no conclusive evidence that considerate use of Clomifen increases the risk. Rarely, a patient can develop ovarian hyperstimulation syndrome OHSS. Such a condition needs immediate medical attention and is considered a severe side effect. Usually, these patients have high AMH levels.
Another side effect is ovarian cysts that can occur weeks after treatment! The cysts are often discovered once we see the patient for another treatment cycle start or in cases of pelvic pain.
The reason behind this is that Clomiphene may remain active in the woman's body for several weeks. The ovaries may continue to stimulate, increasing the occurrence of ovarian cysts.
We sometimes see extreme responses , and we have had patients develop too many eggs - as high seven or eight eggs! Some patients develop the hyperstimulation syndrome and ovarian enlargement and need immediate care by a fertility specialist. While higher-order multiples are rare, patients have conceived triplets using Clomifene alone. Fortunately, the majority of patients develop follicles with the right dose.
Some patients with very severe PCOS show resistance to the medication. While very useful in patients who do not ovulate eggs, some patients show no response because their condition is too severe. Another frequently used term is " Clomid resistant.
In such cases, we need to use injectable gonadotropins like Gonal-F or Follistim to restore the ovulatory cycle. A woman can start taking Clomid tablets between cycle day three and cycle day 5.
One important side effect is the possibility of multiple births. The chance of having more than twins is rare. If your symptoms get worse, you should definitely seek medical attention by contacting myself, your GP or nearest emergency department.
In rare cases, you may need to be hospitalized. Hospitalization may include receiving fluids intravenously through an IV , and they may remove some of the excess fluids in your belly via a needle. You may also be kept in the hospital for careful monitoring until your symptoms lessen.
Usually, symptoms will decrease and go away once you get your period.
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